
When I first made the John Wayne Casserole, I had no idea it would become an instant favorite in my kitchen. This recipe has quickly secured its place as one of the most flavorful and satisfying meals I’ve ever prepared.
It’s the perfect balance of hearty ingredients like beef, cheese, and biscuits with just the right kick of spice. And the best part? It’s all baked into one comforting dish that fills the house with an irresistible aroma. The layers of savory beef, creamy sauce, fresh vegetables, and gooey cheese come together in the most magical way.
Trust me, once you try this casserole, it will become a go-to option for family dinners, potlucks, or even lazy Sunday afternoons when all you want is wholesome comfort food. Now, let’s jump right into what makes this recipe so special!
Why You’ll Love This Recipe?
Simple, Delicious, and Crowd-Pleasing
This casserole is a true time-saver without compromising on flavor. It’s easy to prepare, uses simple ingredients you might already have, and satisfies even the pickiest eaters. The bold flavors combined with creamy layers make it truly unforgettable.
Customizable to Your Taste
You can easily swap or add ingredients to tailor it to your preferences. Whether you prefer a milder flavor or a spicy kick, there’s room to get creative with this dish. A few tweaks, and you’ve got a brand-new take on it every time.
Perfect for Any Occasion
Whether it’s a busy weeknight dinner or a potluck gathering, this casserole is your perfect companion. It’s hearty enough to serve a crowd and still tastes just as amazing as leftovers the next day.
Comfort Food at Its Best
There’s something incredibly satisfying about layered casseroles. They bring home-cooked goodness to your table and deliver that warm, comforting feeling in every single bite.
Cooking Time
Here’s a quick look at how long this recipe will take:
- Prep Time: 15 minutes
- Cooking Time: 45 minutes
- Total Time: 1 hour
Ingredients
Here are the simple ingredients you’ll need to create this flavorful dish:
- Refrigerated biscuits
- Ground beef
- Taco seasoning
- Water
- Onion
- Red bell pepper
- Sour cream
- Mayonnaise
- Shredded Cheddar cheese
- Tomatoes
- Sliced jalapeño peppers (optional)
Variations
If you’re looking for ways to customize this dish, here are some great options:
- Make it Dairy-Free: Swap the sour cream and cheese with plant-based alternatives for a dairy-free version.
- Add Extra Heat: Use spicy taco seasoning, Pepper Jack cheese, or fresh jalapeños for more spice.
- Veggie Boost: Add diced zucchini, corn, or black beans to sneak in more vegetables.
- Use Flavored Biscuits: Try Pillsbury’s cheddar garlic biscuits to elevate the flavor even further.
Equipment You Need
- 9×13-inch baking dish – for the base of the casserole.
- Nonstick skillet – to cook the beef and vegetables.
- Mixing bowls – for combining the creamy topping layers.
- Spatula – to stir ingredients and spread layers evenly.
How to Make John Wayne Casserole?
Prepare the Biscuit Base
Start by preheating your oven to 350°F (175°C). Grease a 9×13-inch pan lightly. Open your can of refrigerated biscuits and press them into the base of the dish and halfway up the sides. Bake for about 15-20 minutes or until lightly golden. 🚪✨ This forms the perfect crust to hold all your delicious layers!
Cook the Beef
Heat a nonstick skillet over medium-high heat. Crumble your ground beef into the pan and cook until it’s browned evenly. Drain any excess fat, then stir in taco seasoning and water. Bring it to a quick boil, reduce the heat, and simmer for a few minutes. This will make your beef layer flavorful and ready to shine! 🥩🌮
Sauté the Vegetables
Using the same skillet, toss in sliced onions and red bell peppers. Sauté them until tender and fragrant. This step enhances the sweetness of the peppers and deepens the dish’s overall flavor profile. 🌶️🍳
Mix the Creamy Layer
Grab a mixing bowl and combine sour cream, mayonnaise, half of the Cheddar cheese, and half of the sautéed vegetables. This creamy mixture is magical and ties everything together once baked. 🧀😍
Layer It All Together
Now comes the fun part! Layer the seasoned beef over your pre-baked biscuit crust. Follow it with sliced tomatoes, the remaining sautéed veggies, and jalapeños for a bit of spice (if you like). Spread the sour cream mixture evenly over the top, then sprinkle the remaining Cheddar cheese. Bake uncovered for 30-40 minutes or until the cheese is bubbly and golden. 🏺❤️

Tips for Making the Recipe
- Temper the Ingredients: Bring the sour cream and mayonnaise up to room temperature before mixing. This prevents curdling when baked.
- Perfect Biscuit Base: Avoid overbaking the biscuits during the initial step since they’ll bake further with the casserole.
- Adjust for Salt: Depending on your taco seasoning, you may want to adjust salt levels. Taste and tweak accordingly!
- Rest Before Serving: Once baked, allow the casserole to rest for 10 minutes. This makes it easier to cut and serve clean slices.
How to Serve John Wayne Casserole?
There are plenty of ways to serve this dish to impress your family or guests. Garnish with freshly chopped cilantro, diced green onions, or a dollop of sour cream for a bright, fresh touch. You can also pair it with a side of guacamole, salsa, or even a simple green salad for a well-rounded meal. Serve the casserole straight out of the dish, or portion it out onto individual plates for a more formal presentation. 🥗🍽️
Nutritional Information
Here’s a quick breakdown of the nutritional content per serving (approx.):
- Calories: 538
- Protein: 21g
- Carbohydrates: 21g
- Fat: 41g
Make Ahead and Storage
This casserole is ideal for meal prepping or making ahead for busy days.
If you’re not serving it right away, you can assemble all the layers (except the cheese) the day before. Store it in the fridge and bake it fresh the next day, adding the cheese just before baking. Leftovers? No worries! Store them in an airtight container and refrigerate for up to 3 days. Reheat individual portions in the microwave or pop the entire dish in the oven at 350°F until warmed through.
For long-term storage, freeze the casserole in a disposable foil pan. Wrap it tightly with plastic wrap and a layer of foil to prevent freezer burn. It can stay frozen for up to 3 months! When you’re ready, bake it straight from the freezer at 350°F, adding a bit more cooking time. 🥶🍴
With its rich layers, captivating flavors, and ease of preparation, this John Wayne Casserole is truly a showstopper that will keep your family coming back for more.
John Wayne Casserole Recipe

When I first made the John Wayne Casserole, I had no idea it would become an instant favorite in my kitchen. This recipe has quickly secured its place as one of the most flavorful and satisfying meals I’ve ever prepared.
Ingredients
- Refrigerated biscuits
- Ground beef
- Taco seasoning
- Water
- Onion
- Red bell pepper
- Sour cream
- Mayonnaise
- Shredded Cheddar cheese
- Tomatoes
- Sliced jalapeño peppers (optional)
Instructions
- Start by preheating your oven to 350°F (175°C). Grease a 9×13-inch pan lightly. Open your can of refrigerated biscuits and press them into the base of the dish and halfway up the sides. Bake for about 15-20 minutes or until lightly golden. This forms the perfect crust to hold all your delicious layers!
- Heat a nonstick skillet over medium-high heat. Crumble your ground beef into the pan and cook until it’s browned evenly. Drain any excess fat, then stir in taco seasoning and water. Bring it to a quick boil, reduce the heat, and simmer for a few minutes. This will make your beef layer flavorful and ready to shine!
- Using the same skillet, toss in sliced onions and red bell peppers. Sauté them until tender and fragrant. This step enhances the sweetness of the peppers and deepens the dish’s overall flavor profile.
- Grab a mixing bowl and combine sour cream, mayonnaise, half of the Cheddar cheese, and half of the sautéed vegetables. This creamy mixture is magical and ties everything together once baked.
- Now comes the fun part! Layer the seasoned beef over your pre-baked biscuit crust. Follow it with sliced tomatoes, the remaining sautéed veggies, and jalapeños for a bit of spice (if you like).
- Spread the sour cream mixture evenly over the top, then sprinkle the remaining Cheddar cheese. Bake uncovered for 30-40 minutes or until the cheese is bubbly and golden.
Notes
- Temper the Ingredients: Bring the sour cream and mayonnaise up to room temperature before mixing. This prevents curdling when baked.
- Perfect Biscuit Base: Avoid overbaking the biscuits during the initial step since they’ll bake further with the casserole.
- Adjust for Salt: Depending on your taco seasoning, you may want to adjust salt levels. Taste and tweak accordingly!
- Rest Before Serving: Once baked, allow the casserole to rest for 10 minutes. This makes it easier to cut and serve clean slices.